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Thread: Hexamita...Info

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    Administrator brewmaster15's Avatar
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    Default Hexamita...Info

    Hexamitiasis
    by Al Sabetta * 2/2002

    Hexamitiasis is an internal *protozoan infection that can afflict most species of fish. *It is caused by *free swimming protozoan organism known as *Hexamita (Formerly known as Octomitis). *This parasite is described as clear, size is *approximately 10 micron, *possesses 8 flagella for locomotion, and can be seen *under a microscope@ 200-400X power. Post mortem identification is made *by *making a squash prep of the intestinal lining , but it is also possible to detect in the feces, and in the shed mucosal lining.

    Most fish can harbor this pathogen in small numbers in their intestinal tracts and show no symptoms what so ever, but there are certain species of fish that are prone to serious illness when infected. Among this group are *Discus , Angels, Oscars, and *African Cichlids in general. *Fish harboring this pathogen in low levels can have it become a serious infection if subjected to stressful conditions such as *overcrowding, poor water quality, poor nutrition, bullying by other fish, *weakened immune system *from other infections. Under these conditions the affected fishes immune system can not adequately control the parasite and it reproduces rapidly causing the acute disease…...HEXAMITIASIS. *Fondly known as HEX. *
    * *
    Symptoms include the following…
    The first indication is a slimy whitish *feces. This feces has components of the mucous lining of the intestine in it. Fish exhibiting this symptom *will still be eating normally at the early stages of the disease As the disease progresses. The fish will often exhibit non typical behaviors such as hiding in the corner, head down. The *fish may stop eating, and *become emaciated. *Laterally compressed fish like discus often show this emaciation in the head region. *The bodies and eyes of the fish often darken. The fish may swim backwards, or swim listlessly.

    Disease Transmission is by contaminated fecal matter. *Cleanliness of the tank *can be a major factor in the *transmission of the disease.



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    Default Re: Hexamita...Info

    Treatments…
     Most authorities recommend using the drug Metronidazole to treat this illness.  It is available at pet  shops under commercial names such as Hexout, Hexamit, etc. It is also available  by  prescription as the drug Flagyl.  The dosage  recommended is typically 250 mg / 10-20 gallons aquarium water. The drug  is absorbed  thru the gills, and works systemically.  Remove carbon during treatment, maintain  biological filtration. The medication is given every other day with  50 % water changes between, for a toatal of 3-5 treatments. Watch water for sign of  water fouling as  the medication is in a sugar base and  bacteria can proliferate..
       If the affected  fish is still eating, it may be given in the food  at a dose of gram/ 4 ounces food.  This is  an excellent  way  to treat  the  illness.  A  week  of such treatment is usually  required. Feed only medicated food during this time

     A note on treatments…. This disease is a very common illness of fish. If you are treating it be sure to fully treat the fish . There is a very real problem with the evolution  of resistence to medications.  Many hobbyist have been reporting hexamita  that seems  resistant to  the drug  metronidazole.  They are reporting  the need  to use a  higher in dose  to cure the ailment. This is a concern because of toxic side effects  of Metronidazole at higher doses.
    Among some groups of hobbyist there is also a treatment  for  Hexamita that uses higher water temperature. Discus and Angel fish  owners report that elevating the water temperature to 92-100 degrees  “cures” the disease.  If your fish can tolerate that temperature it may be worth trying .
       
    Hexamita and Hole in the Head disease. The parasite has been associated with Hole in the Head disease , and  Lateral Line Erosion in some species of fish. There are even commercial medicines to treat these illness  that are treating  them using metronidazole.  The general consensus  is that these  illnesses are nutritional deficiencies, and the causes  for them  are  highly variable.  Any disease state interfering with the uptake of vitamins or minerals is suspect. That includes protozoan infections  like  Hexamita,  and infection by  nematode worms such as  Capillaria,.   The nutritional  cause may also be lack of  certain vitamins (B and D -complexes – author’s guess) that are related to foods being fed, and not disease  at all.  In short , the illnesses are not fully characterized yet.

    Personal note… Since  Hexamita is so common  it is highly  recommended  to  suspect all new  fish of having it, and treat new fish  prophylactically in quaranteen before adding them to your tanks

    Suggestions  for treatment…

    Treating Hexamita with Metronidazole
     
      Dosage source of this info, “Discus  Fish” by Giovanetti.

    .This medication is given  can be given in 2 ways:

      Method 1:  dissolved in a gel food at 1% by food volume = 1gram per 4 oz of food.  (Most  aquarium preps  use capsules containing 250 mg of powdered metronidazole.) Personally, I use flake or tetra bits  as the food here because it is easy to measure, and my fish readily take it. Take the food you will be using  and in a small pan add some hot water until it becomes a watery paste, add  the metronidazole  and then add one packet of Knox gelatin(~7grams). Mix well.  Using aluminum foil make a shallow 1’’ high mold and pour  the food mix into this ,  spread it out so its about  1-2 cm thick, and let set in the refrigerator. Next cut it up into smaller squares  and store  in the freezer. When needed take out one of this small squares and cut it up into to bit size pieces.   I use this  food for until I see no signs of Hexamita (slimy white feces). Then I repeat in 2 weeks  with a 3 day dose  to be sure. When using metro it is recommended to do water changes between doses.

    Method 2:   administered at 250 mg/ 20 gallons of water (some use 250mg/10gal). It is recommended at 3 treatments , every other day, with water changes in between.  The author  follows this  and then puts the  fish on the metro food diet above until I see no sign of Hex.

    Internet resources  for info on Hexamita….

    http://edis.ifas.ufl.edu/BODY_VM053
    http://www.e-aquaria.com/ins_hexamita.html
    http://www.petfish.net/unicell.htm
    http://ae.inno-vet.com/articles/2000/0500/10.htm
         (if anyone has this article- I’d appreciate a copy)


    There are many additional sources  of information  on this disease, and it is generally covered in most fish disease books as well.
    Hth,
    al

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    Default Re: Hexamita...Info

    Supplimental...

    the drug metronidazole, comes in 2 forms... One form is not water soluable,and is best used in food mixes .... This  called metronidazole .

    If the fish is not eating it would be best to try the other form, Dimetronidazole, which is water soluable, and goes into solution very easily.  
      In both cases the drug is absorbed thru the gills when added to the water.
      A good source for Dimetronidazole is  Jehmco.com

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    Registered Member Ardan's Avatar
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    Default Re: Hexamita...Info

    The picture of the "Hexamita Flagellate" below was "used with permission from "Hancbook of Fish Diseases" by TFH Publications, Inc.

    Note the whip like organs called "flagella" that help propel the flagellate through the water.

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    Registered Member Ardan's Avatar
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    Default Re:Hexamita...Info

    Hexamita Pic

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