Partially only. Of course skimmer removes all insoluble organic impurities from water surface but it cannot directly clean water from dissolved organic compounds. It can help you with proper water circulation and greatly improve aeration of the entire tank capacity. It may be also considered as a source of well oxidized water, suitable for further nitrification process and, probably, for oxidation of great part of soluble organic wastes.
If you are familiar with marine tanks then you should consider the Jaubert/Plenum method of filtration. It can work in both marine and freshwater tanks. Plenum allowed me to do WC once monthly (best score- 3 months) with no visible influence on discus health.Would love to know if it works, as it sounds like a good tool to improve water quality in setups where you are not depending on frequent, high-volume, water changes to maintain good water quality.
Hans