Good question. I suspect you'd be OK using prime or safe at double the normal dose, and checking the water quality daily with a seachem ammonia test kit. It's the only one I know of that can tell the difference between free ammonia and ammonium...
Good aeration and siphoning up the poop in the morning, water changes in the evening would probably be OK. Might want to run a canister or powerhead in such a way as to push the detritus to one end, making cleanup easier... PP shouldn't hurt the canister itself...
I'm certainly no expert here, particularly wrt PP, but I have obtained apparent fluke eradication with Clout in BB tanks, dosing every fourth day, three times...